Leukotriene receptor antagonists pranlukast and montelukast for treating asthma

Leukotriene receptor antagonists pranlukast and montelukast for treating asthma.

INTRODUCTION The prevalence of bronchial asthma, which is a chronic inflammatory disorder of the airway, is increasing worldwide. Although inhaled corticosteroids (ICS) play a central role in the treatment of asthma, they cannot achieve good control for all asthmatics, and medications such as leukotriene receptor antagonists (LTRAs) with bronchodilatory and anti-inflammatory effects often serve...

Leukotriene receptor antagonists pranlukast and montelukast for treating asthma

Introduction The prevalence of bronchial asthma, which is a chronic inflammatory disorder of the airway, is increasing worldwide. Although inhaled corticosteroids (ICS) play a central role in the treatment of asthma, they cannot achieve good control for all asthmatics and medications such as leukotriene receptor antagonists (LTRAs) with bronchodilatory and anti-inflammatory effects often serve ...

195 The Impact of Administration of Leukotriene Receptor Antagonists, Pranlukast-EK to Infants with Bronchial Asthma

increased the time to first asthma deterioration thus decreasing the proportion of subjects experiencing asthma deterioration during the study (MF/F 1⁄4 16.5%; versus MF 1⁄4 28.2% [P 1⁄4 0.006]; versus F 1⁄4 44.7% [P , 0.001]; and vs placebo 1⁄4 45.7% [P , 0.001]). Mean FEV1 AUC0–12h over baseline at week 12 were MF/F 1⁄4 4.00 L · h; MF 1⁄4 2.53 L · h; F 1⁄4 3.83 L · h; and placebo 1⁄4 1.11 L ·...

Role of leukotriene receptor antagonists in asthma.

Asthma is a chronic inflammatory disease that affects >300 million people worldwide. However, inhaled corticosteroids (ICS), the gold standard therapy for persistent asthma, cannot suppress every component of airway inflammation and often fail to adequately penetrate the small airways in order completely suppress eosinophilia. Cysteinyl leukotrienes are important inflammatory factors that are i...

Leukotriene receptor antagonists: useful in acute asthma?